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Pharmacokinetics of Tobramycin and Ceftazidime

Question
I am a medicines information pharmacist at Alder Hey in Liverpool and I have been asked to look into the evidence behind the use of twice daily IV tobramycin and ceftazidime, which one of our shared care centres uses. I can see in the CF trust antibiotic guidelines it states that the total daily dose of ceftazidime can be given in two divided doses but it does not mention this for tobramycin. I was wondering if you have any information on the evidence behind giving these drugs twice daily instead of three times a day or once daily for tobramycin and is there any data on the pharmacokinetics of these drugs in CF patients?
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10.08.2009
The answer is edited by: Prof Judy Bradley