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Amiloride Preparation

Question
I would like to ask about the preparation of amiloride solution in our pharmacy. Does it have to be sterile even though our doctor doesn´t specify the need for sterilisation on the prescription?
Answer
Hello,

We presume you mean the preparation of amiloride in small 20ml bottles. That is the only proper way of administering the medicine. Large 1 litre bottles, which are opened twice a day within the course of 1 month, are highly unsuitable, as there is a great danger of infection.

Amiloride solution isn´t sterilised during preparation in a pharmacy – that is why your doctor does not request it. The solution is filtered through a special filter and it is free of microbes, but it isn´t sterile. It doesn´t need to be sterile, as it isn´t administered intravenously, but through inhalation into airways. Even the air we breathe isn´t sterile. You needn´t be afraid – the solution is definitely harmless.
Dr. J. Brázová
15.11.2011