vaccine against Pseudomonas and Staphyloccocus

Question

Hello,
I have heard of vaccine clinical trial phase II and III called IC43 (pseudomonas) and V710 (staphyloccocus).
Do you know more?

Answer

Hello,

Indeed, a phase II/III clinical trial is ongoing in Europe regarding Pseudomonas vaccine:
www.clinicaltrials.gov/ct2/show/NCT01563263?term=%22vaccine%22+AND+%22pseudomonas%22&rank=1

800 patients (over 18 years admitted to an ICU with need for mechanical ventilation for at least 48 hours) should be included.
Patients will receive (according to randomization):
- 2 vaccines injections IC43 at J0 and J7
- or a placebo
The study should be completed in 2015.

About the vaccine against Staphylococcus (V710), a phase I trial in healthy volunteers showed that injection of V710 resulted in an immune response (production of antibodies against Staphylococcus).
These results prompted a phase II trial in patients with end-stage renal disease who were on chronic hemodialysis. But the results of this clinical trial were inconclusive: the vaccine induced production of antibody against Staphylococcus, but it has not been possible to prove protection of patients against infection.
In addition, a study in patients undergoing cardiothoracic surgery showed disappointing results for V710 used as preventive.

I hope I have answered your question.
Best regards,
Anna Ronayette

04.03.2013