User login

Enter your username and password here in order to log in on the website:

Forgot your password?

Please note: While some information will still be current in a year, other information may already be out of date in three months time. If you are in any doubt, please feel free to ask.

vaccine against Pseudomonas and Staphyloccocus

I have heard of vaccine clinical trial phase II and III called IC43 (pseudomonas) and V710 (staphyloccocus).
Do you know more?

Indeed, a phase II/III clinical trial is ongoing in Europe regarding Pseudomonas vaccine:

800 patients (over 18 years admitted to an ICU with need for mechanical ventilation for at least 48 hours) should be included.
Patients will receive (according to randomization):
- 2 vaccines injections IC43 at J0 and J7
- or a placebo
The study should be completed in 2015.

About the vaccine against Staphylococcus (V710), a phase I trial in healthy volunteers showed that injection of V710 resulted in an immune response (production of antibodies against Staphylococcus).
These results prompted a phase II trial in patients with end-stage renal disease who were on chronic hemodialysis. But the results of this clinical trial were inconclusive: the vaccine induced production of antibody against Staphylococcus, but it has not been possible to prove protection of patients against infection.
In addition, a study in patients undergoing cardiothoracic surgery showed disappointing results for V710 used as preventive.

I hope I have answered your question.
Best regards,
Anna Ronayette