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Usage of Sinupret®
- Question
- Dear ladies and gentlemen,
the company Bionorica advertises its preparation Sinupret® (here especially Sinupret extract®) that it positively influences the CFTR-channels of the airway mucosa in healthy people suffering from an acute or also chronic rhinossinusitis. Namely in the way that the mucociliary clearance would improve because of liquefaction of the viscous brine phase on the inflammed mucosa. What is the situation like in CF patients? Can somebody who has e.g. a reduced numer or a reduced acitivty of these channels profit from a long-term intake of Sinupret® (my pharmacist assumed this)? Is there any experience on this?
Thank you for your answer and best regards - Answer
- Hello,
herbal drugs for liquefaction like Sinupret®, Gelomyrtol® and Soledum® have partly better study data as acetylcystein or ambroxol, for whom the proof of a clear effectiveness is still outstanding.
For myself and my patients without CF I therefore really like to use this drugs and, as I think, also with good success. Therefore I also gave my CF patients those herbals drugs early in case of complaints about rhionsinusitis. Success has nearly exclusively been reported to me from CF patients with mild/atypical CF, in whom I would expect a residual function of the CFTR channel.
Therefore I assume, without being able to proof it with data, that the for me noticable liquefaction of secretions due to these drugs can only hardly or not be achieved at all in case of typical CF. These are only experience reports but however not a scientific clarification of this interesting question, that for sure could be clarified in a model.
In summery, I would therefore consider indeed an individual therapeutical trial in case of acute rhinosinusitis and CF to be sensible - especially in case of mild/atypical CF. A long-term intake, however, does not seem sensible to me. In case of a missing immediate effect, that is reported when using it in the acute phase of a rhinosinusitis without CF, the continuation does not seem sensible to me either.
Yours sincerely,
PD Dr. J. Mainz - 20.11.2013
