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Pseudomonas aeruginosa

Question
Hello,
My 3 old-year daughter is colonized with Pseudomonas aeruginosa for 1 year. She is treated by intravenous antibiotics (ceftazidime + tobramycine) every 3 months. May the Pseudomonas aeruginosa become resistant to this treatment ? If yes, how long is it to be resistant? In case of resistance, is it life-threatening? Thanks for your response.
Answer
Hello and thanks for your question.
Pseudomonas aeruginosa may become resistant progressively to the different antibiotics we give to treat it. This bacteria owns a lot of defensive and protective mechanisms against its environment (other bacteria, antibiotics …). It’s impossible to give you a delay for acquiring resistance to antibiotics. This phenomenon is highly variable from a patient to another, from a Pseudomonas to another, and from an antibiotic to another. Resistance to antibiotics is not life-threatening by itself. Often we can use other anti-Pseudomonas antibiotics than that used for your daughter. Alternating the different antibiotics used for intravenous treatments may slow down the phenomenon.
I hope to have answered to your question.
With my best regards,
Prof Jean-Chrsitophe Dubus
08.04.2014