Pseudomonas - inhalation with gentamycin

Question

Hello dear expert team,
Pseudomonas has been found in my samples. Therefore I am told to inhale for 3 months with gentamycin (mixture of gentamycin and NaCl solution). For this I got gentamycin solution for i.v. application. Can one indeed inhale this i.v. solution? Nothing is said about this in the leaflet. Is this kind of therapy advisable from your standpoint respectively successful? Many thanks for your advice!

Answer

Dear questioner,
we assume, that your are a CF patient as you turn to the CF expert team. We will therefore answer your question in the connection with Pseudomonas-finding based on the underlying disease of CF.
We also assume, that you talk about Pseudomonas aeruginosa and not about another kind of Pseudmonas?
Assumed that you have CF and the Pseudmonas aeruginosa germ has been found there is indeed the indication for an inhalative therapy with an antibiotic. This therapy can for example be done with an aminoglycoside (gentamycin is also an aminoglycoside). For the inhalation with an aminoglycoside however, not gentamycin (no license for inhalation) is taken, however tobramycin. Tobramycin is licensed for the inhalation against Pseudomonas aeruginosa infections of the airways in the form of different preparations and different dosages (e.g. Tobi®, Bramitob®, Ventobra®, Gernebcin®). Your physician has to decide about the preparation and the dosage. In the single case also gentamycin injection solution can be inhaled on the recommendation of your physician. However we do not recommend this. Please talk to your physician and point on the licensed tobramycin preparations.

I hope to have helped you with this information.
Yours sincerely,
Yours
Dr. Christina Smaczny

03.12.2015