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Hydrogen peroxide

Question
I have read, that 0.3% hydrogen peroxide could be helpful if used with a nebulizer in case of lung diseases. Furthermore it says that i.v. treatments in case of COPD/emphysema can stop the progress of the illness and partly even improve it. Are there any experiences in connection to CF? I could imagine that hydrogen peroxide could also have unfavoulrable effects as an oxidant...?
Best regards,
IE
Answer
Hello,
hydrogen peroxide (H2O2) is in general a very reactive substance, it provides reactive oxygen metabolites (ROMs) that could be very harmful. For sure one can dilute the substance in a way, that it does not come immediately to unfavourable effects, if this is secure, then, I cannot judge as studies are lacking. However we assume in case of chronic inflammation of CF that too many ROMs lead to oxidative stress, so that for suppression more antioxidants are needed. However, there are no licensed antioxidants.
Best regards,
Prof. Dr. TOF Wagner
03.01.2016