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Combination of the mutations c.650A>G and F508del

Question
Dear expert team,
In the frame of the genetic counseling the named mutations have been found in my boyfriend (F508del) and in me (c.650A>G). We are aware of the fact, that in case of family planning the probability is 25% to get a child suffering from CF.
1) Do you know anything about this combination?
2) How could the course of the illness be?
3) C.650A>G is a very rare mutation and we have been told, that it could rather be classified as to be mild. I have read in this forum, that a mild mutation would be essential for the prognosis. Could you make a statement concerning this concrete combination?
I thank you very much for your answer.
Answer
Dear questioner,
I am sure, that we could not add anything essential to the genetic counseling – about c.650A>G nothing in detail is known, in contrast to F508del, as this variant is too seldom. Also about the combination of those two mutations, there is no hard data available, either – that means, there are not enough patients known (with F508del/c.650A>G), so that one cannot predict the course of the illness.
The corresponding reference data base CFTR2 (cftr2.org) has actually information about 88000 patients from worldwide 41 countries. On this website you can found information about those CFTR-gene mutations, that are frequent enough, in order to classify them clinically. c.650A>G is not enrolled in this list and I would like to follow the curators of CFTR2: for c.650A>G there is no prediction on the picture of the illness possible.
With my best regards for your future,
Frauke Stanke
04.06.2016