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Inheritance
- Question
- If I am a carrier (not ill) of a defective CF gene, have both of my parents to be carriers in order to give it to me or is it sufficient, if only one of my parents is a carrier?
Many thanks for your answer. - Answer
- Hello,
you ask if both of your parents have to be carriers for CF, if you are not ill yourself but are only carrier.
Each healthy human being has 23 chromosome pairs. During conception, from each parent a single set of 23 chromosomes meets in the eg cell. Therefore, the developing child has again a double set of 23 chromonse pairs. A healthy carrier has on only one of his chromosomes number 7 a mutation for CF, while on the other chromonsome, there is no CF mutation. This means, that theoretically both parents could have been carriers, that means both could each be carriers of a healthy and a mutated CF gene. Indeed only one parent has transmitted the CF mutation to you. Therefore it could also be, that only one parent of yours is a CF carrier. You can get more information on Wikipedia "autosomal-recessive inheritance"
Best regards,
Dr. H.-G. Posselt - 26.05.2017
