Forgot your password?

Please enter your username or email address. Instructions for resetting the password will be immediately emailed to you.
Reset Password

Return to login form 

Please note: While some information will still be current in a year, other information may already be out of date in three months time. If you are in any doubt, please feel free to ask.

Pancreatic sufficiency

Question
Hello,

My 7 month old baby has CF (26AG and G542X mutations), it is currently pancreatic sufficient.
If it lasts over time, from what age on can we expect him to be pancreatic insufficient and it will remain for life?

thank you
Answer
Hello,

CF patients are pancreatic insufficient in the majority of cases (80-85%). However, some mutations are known to be associated more frequently with pancreatic sufficiency. "26AG" is not a complete name: perhaps is it the mutation 3272-26A> G? In this case, more than half of the patients with this mutation are pancreatic sufficient.

The status of pancreatic sufficient may change over time, particularly during the first years of life. The recommendations are therefore to control fecal elastase regularly once a year during this period, then to check in case of gastrointestinal symptoms suggestive of exocrine pancreatic insufficiency (difficult weight gain, abdominal pain, abnormal stools).

Kind regards
Dr Michèle Gérardin
19.07.2015