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Trikafta and transplantation
- Frage
- Hello,
my son is 20 years old, and is a CF patient with one deltaF508 mutations. Due to his extremly worsened lung function, his CF center recommended to take Trikafta. He got a liver transplant in 2017; this is the reason why he should discuss the take with his CF center. The center, however has no experience with transplanted patients and Trikafta.
Do you have any information? - Antwort
- Dear questioner,
there is no data concerning the efficacy and saftey of the drug in patients who underwent a transplantation. Therefore, the intake of the medication is not recommended. There is no information about drug interactions with immuno-suppressive drugs like cyclosporin, everolimus, sirolimus or tracrolimus. Therefore it is not recommended to take those drugs together with Trikafta.
This is the data, however, the decision, if a transplanted CF-patient should take a mutation-specific drug like Kalydeco, Orkambi, Symkevi or Trikafata remains an individual decision as an individual treatment effort.
Best regards,
Dr. Ch. Smazcny - 11.05.2020