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Intake of Trikafta (Kaftrio/Kalydeco)

Question
Dear experts,
I have heard, that some patients change the intake of Trikafta (Kaftrio [Elexacaftro/Tezacaftor/Ivacaftor]/ Kalydeco [Ivacaftor]).
Instead of taking 2 pills of Kaftrio in the mornings and 1 pill of Kalydeco in the evenings, they take 1 pill of Kalydeco in the mornings and 2 pills of Kaftrio in the evenings.
Are there any concerns about this?
I have the impression that I cannot sleep after having taken Kalydeco (Ivacaftor). Therefore I think of changing the intake or leaving out the evening intake of Kalydeco at all.
Many thanks for your answer
Answer
Dear patient,
after contacting the producing company and also after consulting other CF experts, there are no concerns regarding the switch of the morning and evening intake of Trikafta (Kaftrio/Kalydeco). Therefore you can try that, but we dehort from leaving out the eventing dosage, as the drug will be not effective due to the pharmacocinetics.
Best regards,
Daniela d'Alquen
15.02.2021