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Chance of CF in the fetus
- Question
- Hello, in the prenatal test for me, the mutation c.2620-15C>G in the CFTR gene was found, which is characterized as a possibly non-pathogenic polymorphism, and for my husband, c.3718-24G>A was found, which is characterized as possibly non-pathogenic/unspecified of clinical significance. What is the probability that the fetus will show both polymorphisms and what is the probability that it will suffer from CF.
- Answer
- The c.2620-15C>G and c.3718-24G>A variants in the CFTR gene are characterized as non-pathological. This means that even if the fetus inherits these two variants (25% chance) it will not suffer from cystic fibrosis.
In order to calculate the probability that the fetus is suffering, it is necessary to know what test you have done. If you have had the full test and the only findings are the ones you report then the chance of cystic fibrosis in the fetus is almost zero.
P. Myrto - 22.09.2024
