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NB-401
- Question
- I vaguely heard of NB-401. It is an aerosol that would combat bacterial strains highly resistant to current treatments.
Could you tell me a little more? ongoing studies?
Thanks a lot for your response - Answer
- Hello,
The nano-emulsions are preparations containing water droplets or oil of nanometric size, which can be prepared using ultrasound.
Some nano-emulsions have antimicrobial and antiviral properties.
The nano-emulsion NB-401 (company NanoBio, USA) is manufactured by emulsification of cetylpyridinium chloride (CPC), poloxamer 407 and ethanol in water with soybean oil using a high speed emulsifier.
A study was conducted to test the activity "in vitro" of NB-401 on a panel of multi-resistant bacteria from patients with cystic fibrosis.
The results conclude to a potential role of NB-401 as an antimicrobial agent for the treatment of infection due to opportunistic pathogens in the context of this disease. These pathogens should not develop resistance to a nanoemulsion due to his mechanism: interaction with the membrane and cause bacterial lysis.
Toxicity studies after inhalation of NB-401 by animals have been completed. No complications were noted and the animals tolerated the treatment.
So NB-401 could be used with other treatments nebulization in patients with cystic fibrosis to combat infection.
It is a trail to follow, but to our knowledge there are no ongoing clinical trial to date.
Anna Ronayette
The firm's website provides some information on NB-401: www.nanobio.com/Anti-infectives/Cystic-Fibrosis.html
- 12.04.2011
